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《医学前沿(英文)》 2015年 第9卷 第3期 页码 261-274 doi: 10.1007/s11684-015-0406-y
Environmental pollution is one of the main causes of human cancer. Exposures to environmental carcinogens result in genetic and epigenetic alterations which induce cell transformation. Epigenetic changes caused by environmental pollution play important roles in the development and progression of environmental pollution-related cancers. Studies on DNA methylation are among the earliest and most conducted epigenetic research linked to cancer. In this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicine were summarized, and the effects of environmental pollutants, particularly air pollutants, on DNA methylation were introduced. Furthermore, prospective applications of DNA methylation to environmental pollution detection and cancer prevention were discussed.
关键词: environmental pollution DNA methylation cancer biomarker diagnosis therapy prevention
Zixuan CHEN; Tao LIU; Xiao MA; Hanyu TANG; Jianyou HUANG; Jianzhong PEI
《结构与土木工程前沿(英文)》 2022年 第16卷 第7期 页码 896-908 doi: 10.1007/s11709-022-0856-7
关键词: honeycomb structure plastic pavement dimension optimization mechanical response factor significance
LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei
《医学前沿(英文)》 2008年 第2卷 第1期 页码 87-94 doi: 10.1007/s11684-008-0016-z
ZHU Lidong, CHEN Xiaoping
《医学前沿(英文)》 2007年 第1卷 第4期 页码 364-368 doi: 10.1007/s11684-007-0070-y
Insult of gastroesophageal reflux on airway: clinical significance of pharyngeal nozzle
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 117-122 doi: 10.1007/s11684-014-0343-1
At the very time of global paying the highest attention to the worst insults of smoking as well as haze on the airway, everybody knows both are exogenous and noticeable. However, people mostly, including many medical personnel, do not know how badly the gastroesophageal reflux (GER) insults on our own airway. Symptoms of GER are commonly seen as heartburn and regurgitation, which can be mostly tolerated. However, when the up going gastric content reversely passes the esophagus and then the distal pharynx, where it appears a beak like stricture, serving as a nozzle, so as to produce numerous micro-particles and reach the oro-nasal cavity and also the airway causing allergic rhinitis and asthmatic attacks, even pulmonary parenchyma lesions. It will reduce life quality or even jeopardize life. The point that the endogenous insult appears in the respiratory system, but originates from the digestive tract is not well known and often undiagnosed and not correctly treated. The GER induced airway challenge is a treatable and preventive entity, as soon as a diagnosis is made, a good relief could be expected by means of life style adjustment, medicine, or fixation of the patulous cardia through radiofrequency or fundoplication. The author Dr. Zhonggao Wang had suffered it for long and symptoms disappeared for 8 years after anti-reflux surgery. Here is a presentation of Dr. Zhonggao Wang and his team’s work and would call attention to the public so as to recognize this relatively unknown entity — a treatable condition occurring from human itself, but not from outside surroundings as smoking or haze does.
关键词: gastroesophageal reflux airway pharyngeal nozzle micro-aspiration asthma
Xiaocong LI,
《结构与土木工程前沿(英文)》 2009年 第3卷 第4期 页码 445-454 doi: 10.1007/s11709-009-0063-9
关键词: information management established appreciation practical
Clinical significance of human papilloma virus infection in the cervical lesions
Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA
《医学前沿(英文)》 2010年 第4卷 第3期 页码 264-270 doi: 10.1007/s11684-010-0094-6
关键词: cervical lesion high risk-human papilloma virus persistent infection loading dose cervical intraepithelial neoplasia cervical cancer
RULKENS Wim
《环境科学与工程前沿(英文)》 2008年 第2卷 第4期 页码 385-396 doi: 10.1007/s11783-008-0073-1
Significance of using isolated footing technique for residential construction on expansive soils
Harry FAR,Deacon FLINT
《结构与土木工程前沿(英文)》 2017年 第11卷 第1期 页码 123-129 doi: 10.1007/s11709-016-0372-8
关键词: expansive soils residential slabs isolated footings Australian Standards
Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance
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《医学前沿(英文)》 2012年 第6卷 第4期 页码 376-380 doi: 10.1007/s11684-012-0228-0
The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.
关键词: FOXO3a FOXM1 transcription factor cancer drug resistance tumorigenesis
Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer
null
《医学前沿(英文)》 2014年 第8卷 第1期 页码 96-100 doi: 10.1007/s11684-014-0316-4
Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer. Moreover, the impact of para-aortic lymph node (PAN) removal on patient prognosis is still unclear. In this study, 80 patients were divided into groups A and B. Group A consisted of 30 patients who underwent PAN+ pelvic lymph node (PLN) dissection, whereas group B consisted of 50 patients who only underwent PLN dissection. Analysis of the correlation between PAN clearance and prognosis in epithelial ovarian cancer was conducted. Nineteen cases of lymph node metastasis were found in group A, among whom seven cases were positive for PAN, three cases for PLN, and nine cases for both PAN and PLN. In group B, 13 cases were positive for lymph node metastasis. Our study suggested that the metastatic rate of lymph node is 40.0%. Lymph node metastasis was significantly correlated with FIGO stage, tumor differentiation, and histological type both in groups A and B (P<0.05). In groups A and B, the three-year survival rates were 77.9% and 69.0%, and the five-year survival rates were 46.7% and 39.2%, respectively. However, the difference was not statistically significant (P>0.05). The three-year survival rates of PLN metastasis in groups A and B were 68.5% and 41.4%, and the five-year survival rates were 49.7% and 26.4%, respectively. Furthermore, PLN-positive patients who cleared PAN had significantly higher survival rate (P=0.044). In group A, the three-year survival rates of positive and negative lymph nodes were 43.5% and 72.7%, and the five-year survival rates were 27.2% and 58.5%, respectively. The difference was statistically significant (P=0.048). Cox model analysis of single factor suggested that lymph node status affected the survival rate (P<0.01), which was the death risk factor. Consequently, in ovarian carcinoma cytoreductive surgery, resection of the para-aortic lymph node, which has an important function in clinical treatment and prognosis of patients with ovarian cancer, is necessary.
关键词: ovarian cancer para-aortic lymph node pelvic lymph node
郎景和
《中国工程科学》 2009年 第11卷 第10期 页码 137-142
子宫内膜异位症是严重影响育龄妇女健康及生育的常见病、多发病。课题组在该病的基础与临床研究过程中,形成了独到的病因学观点。即认为,内异症是由异常的子宫在位内膜组织随经血逆流至盆腹腔,在异地完成粘附、侵袭、血管形成之病理过程,而形成病灶。致病的关键系子宫在位内膜本身,而在位内膜干/祖细胞或其微环境的改变可能是根本原因。此外,内异症还表现出类肿瘤特质。上述病因学研究结果推进了临床诊疗技术和水平。近年来在位内膜标志物的检测和局部治疗更反映了“源头”诊疗的新观念。对内异症发病机制的再认识和新观念,直接影响了临床问题解决的新方向。
Effect of oxytocin on gastric ischemia-reperfusion injury in rats
ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming
《医学前沿(英文)》 2007年 第1卷 第4期 页码 433-437 doi: 10.1007/s11684-007-0085-4
关键词: control significant difference surgical statistical significance Sprague-Dawley
LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes
Shiguo XIAO; Shaohong LI
《结构与土木工程前沿(英文)》 2022年 第16卷 第7期 页码 871-881 doi: 10.1007/s11709-022-0863-8
关键词: slope stability safety factor failure criterion least square support vector machine
lncR-GAS5 upregulates the splicing factor to impair endothelial autophagy, leading to atherogenesis
《医学前沿(英文)》 2023年 第17卷 第2期 页码 317-329 doi: 10.1007/s11684-022-0931-4
关键词: lncR-GAS5 miR-193-5p splicing factor SRSF10 autophagy atherogenesis
标题 作者 时间 类型 操作
Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications
null
期刊论文
Structural dimension optimization and mechanical response analysis of fabricated honeycomb plastic pavement slab
Zixuan CHEN; Tao LIU; Xiao MA; Hanyu TANG; Jianyou HUANG; Jianzhong PEI
期刊论文
Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of
LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei
期刊论文
Change and significance of T-cell subsets and TNF-α in patients with advanced malignant obstructive jaundice
ZHU Lidong, CHEN Xiaoping
期刊论文
Scientific significance of ancient maps of Yellow River and Grand Canal for water conservancy in China
Xiaocong LI,
期刊论文
Clinical significance of human papilloma virus infection in the cervical lesions
Shuang LI, Yu-Han MENG, Hu TING, Jian SHEN, Ding MA
期刊论文
Increasing significance of advanced physical/chemical processes in the development and application of
RULKENS Wim
期刊论文
Significance of using isolated footing technique for residential construction on expansive soils
Harry FAR,Deacon FLINT
期刊论文
Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer
null
期刊论文
Effect of oxytocin on gastric ischemia-reperfusion injury in rats
ZHANG Wenwen, ZHANG Jianfu, ZHANG Yongmei, XU Ming
期刊论文
LSSVM-based approach for refining soil failure criteria and calculating safety factor of slopes
Shiguo XIAO; Shaohong LI
期刊论文